The Astros are on the clock. The Twins won today, ending their 11-game losing streak and assuring Houston of the top pick in the 2012 draft. As our Reverse Standings page shows, there's no way that the Twins will finish with a worse record than the Astros this year.
The Astros will finish with at least 102 losses (even if they don't lose again) and the Twins reached the 60-win plateau with today's win, which means they won't exceed 102 losses. Because the Astros finished with a worse record (73-78) than the Twins (91-60) a year ago, Houston would win a tiebreaker and select first overall in 2012 should both clubs happen to finish 60-102 this year.
Houston has selected first overall twice before, though both selections came long before they hired current scouting director Bobby Heck. Houston selected Floyd Bannister first overall in 1976 and selected Phil Nevin with the top choice in 1992, five picks ahead of Derek Jeter.